treatment

Rating: Unknown effectiveness

Transcranial magnetic stimulation and transcranial direct current stimulation were found in a narrative review (without meta-analysis) (Rachid,  2018, 10 clinical studies, n=195)  to have:

  • no significant effect on reducing substance use.

There were some indications of positive results in safety and reduction of cocaine cravings.

Name of response option

  • pharmacological treatment, assisted withdrawal

Desired outcome(s)

  • reduce substance use

Area(s)

  • Treatment

Specific substance or pattern of use

cocaine
Rating: Unknown effectiveness

Opium withdrawal presents significant symptoms, even if milder than heroin withdrawal. Pharmacologically assisted withdrawal was found to have no effect in a systematic review (Rahimi-Movaghar et al, 2018, 13 studies, N=1096) in:

  •      improving treatment outcomes.

Tested medications include the following (individually or combined, and/or in different dosages): baclofen, clonidine, amantadine, buprenorphine, methadone, tramadol, gabapentin, tincure of opium.

While all these may be useful in alleviating the symptoms, there is no clear evidence as to whether any of the medications is more effective than the others in the management of opium withdrawal.

Name of response option

  • assisted withdrawal

Desired outcome(s)

  • improve treatment outcomes

Area(s)

  • Treatment

Specific substance or pattern of use

opioids
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